diff --git a/gdb/breakpoint.c b/gdb/breakpoint.c
--- a/gdb/breakpoint.c
+++ b/gdb/breakpoint.c
@@ -15441,6 +15441,50 @@ static struct cmd_list_element *enablebreaklist = NULL;
 
 cmd_list_element *commands_cmd_element = nullptr;
 
+void
+breakpoints_relocate (struct objfile *objfile, struct section_offsets *delta)
+{
+  struct bp_location *bl, **blp_tmp;
+  int changed = 0;
+
+  gdb_assert (objfile->separate_debug_objfile_backlink == NULL);
+
+  ALL_BP_LOCATIONS (bl, blp_tmp)
+    {
+      struct obj_section *osect;
+
+      /* BL->SECTION can be correctly NULL for breakpoints with multiple
+         locations expanded through symtab.  */
+
+      ALL_OBJFILE_OSECTIONS (objfile, osect)
+	{
+	  CORE_ADDR relocated_address;
+	  CORE_ADDR delta_offset;
+
+	  delta_offset = ANOFFSET (delta, osect->the_bfd_section->index);
+	  if (delta_offset == 0)
+	    continue;
+	  relocated_address = bl->address + delta_offset;
+
+	  if (obj_section_addr (osect) <= relocated_address
+	      && relocated_address < obj_section_endaddr (osect))
+	    {
+	      if (bl->inserted)
+		remove_breakpoint (bl);
+
+	      bl->address += delta_offset;
+	      bl->requested_address += delta_offset;
+
+	      changed = 1;
+	    }
+	}
+    }
+
+  if (changed)
+    qsort (bp_locations, bp_locations_count, sizeof (*bp_locations),
+	   bp_locations_compare);
+}
+
 void
 _initialize_breakpoint (void)
 {
diff --git a/gdb/breakpoint.h b/gdb/breakpoint.h
--- a/gdb/breakpoint.h
+++ b/gdb/breakpoint.h
@@ -1664,6 +1664,9 @@ extern const char *ep_parse_optional_if_clause (const char **arg);
    UIOUT iff debugging multiple threads.  */
 extern void maybe_print_thread_hit_breakpoint (struct ui_out *uiout);
 
+extern void breakpoints_relocate (struct objfile *objfile,
+				  struct section_offsets *delta);
+
 /* Print the specified breakpoint.  */
 extern void print_breakpoint (breakpoint *bp);
 
diff --git a/gdb/objfiles.c b/gdb/objfiles.c
--- a/gdb/objfiles.c
+++ b/gdb/objfiles.c
@@ -875,6 +875,11 @@ objfile_relocate1 (struct objfile *objfile,
 				obj_section_addr (s));
     }
 
+  /* Final call of breakpoint_re_set can keep breakpoint locations disabled if
+     their addresses match.  */
+  if (objfile->separate_debug_objfile_backlink == NULL)
+    breakpoints_relocate (objfile, delta);
+
   /* Data changed.  */
   return 1;
 }

